Protein Binding Assays Market Expected To Witness A Substantial Growth Of $683.09 Million By 2026: Grand View Research Inc.

 

The global protein binding assays market size is expected to reach USD 683.09 million by 2026 at a CAGR of 10.6%, according to a new report by Grand View Research, Inc. Protein binding assays are increasingly being adopted in preclinical stages of drug discovery & development programs. These assays help in detection of target molecules and provide critical information about the properties of therapeutics and biologics.

Increase in number of R&D outsourcing activities by pharmaceutical companies for development of therapeutics is anticipated to increase the adoption of protein binding assays. Presence of several companies that provide these services for molecule investigation and analysis is expected to positively impact the market growth over the forecast period.

These assays provide help understand ADME properties during selection and development of therapeutic candidates. Estimation of safety margins during drug development is an important step that can be carried out by quantification of binding of new chemical entities to a protein.

According to U.S. FDA, 59 novel therapeutics and biologics were approved by Center for Drug Evaluation and Research (CDER) in 2018 as compared to 46 new drugs approved in 2017. Therefore, increase in the number of drug candidates being screened and approved annually drives the adoption of protein binding assays. Pharmaceutical companies are investing in preclinical screening activities for preventing late-stage failures in development of therapeutics. As per the estimates, in June 2018, a majority of pharmaceutical firms invested approximately USD 1.13-5.65 million in preclinical testing.

Drug discovery & development is cost-intensive and requires high capital investment, technological capabilities, and human resources. If the drug candidate fails during the development stages, manufacturers incur a substantial loss. Protein binding assays help optimize drug discovery costs by analyzing the binding & absorption capabilities in preclinical phases, thus reducing drug attrition in late stages of drug development.

Introduction of advanced methods, such as in situ protein-protein interaction assay, that are more sensitive than conventional techniques are expected to boost adoption of these assays in laboratories. In addition, implementation of parallel testing for statistical analysis of assays used for determining potency is expected to fuel research activities in this market.

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Protein Binding Assays Market Report Highlights

• Equilibrium dialysis accounted for the largest share and is expected to maintain its dominance over the forecast period
• This is because equilibrium dialysis is an extensively used method to detect free drug fraction as it is less susceptible to experimental artifacts
• Instruments segment is expected to grow at the fastest CAGR due to rising demand for automated, user-friendly systems that help determine the distribution capacity of drug candidates
• Assay services offered by a large number of biotechnology players can be attributed to the segment’s largest revenue share in 2018
• Increase in number of CROs offering customized, comprehensive, and economical protein binding assay services to support pharmaceutical firms is expected to boost growth of CROs segment
• Pharmaceutical firms are investing significantly in preclinical drug discovery studies to meet the growing demand for therapeutics resulting in the largest protein binding assays market share of the segment
• Presence of leading players providing such assays and high R&D investment for therapeutic development can be attributed to the dominant share of North America
• Asia Pacific is expected to witness fastest growth due to low cost of preclinical methods, which increases outsourcing of services to the region
• Companies such as Thermo Fisher, Charles River, Sovicell, GE Healthcare, Evotec, and others have undertaken several strategic initiatives to enhance their market presence

Key players operating in the market include Thermo Fisher Scientific, Inc.; Charles River; Sovicell GMBH; Absorption Systems LLC; GE Healthcare; Eurofins Scientific; 3B Pharmaceuticals; Creative Biolabs; Evotec (Cyprotex); and Bioduro. Market players are undertaking several strategic initiatives to strengthen protein binding assays portfolio and increase their footprint in the market. Some of the strategies implemented include agreements, collaborative models, business expansion, and product developments.

For instance, in March 2018, Thermo Fisher signed an agreement with Montreal Neurological Institute, under which the institute generated cell lines by using Fisher’s antibodies and protein binding assays to study neurodegenerative diseases. Similarly, in February 2019, Charles River signed an agreement to acquire Citoxlab to strengthen its market position in the field of drug discovery & development.

About Grand View Research

Grand View Research, Inc. is a U.S. based market research and consulting company, registered in the State of California and headquartered in San Francisco. The company provides syndicated research reports, customized research reports, and consulting services. To help clients make informed business decisions, we offer market intelligence studies ensuring relevant and fact-based research across a range of industries, from technology to chemicals, materials and healthcare.