Protein Stability Analysis Market is Predicted to Observe a Tremendous Growth, With a CAGR of 10.8% From 2020 To 2026: Grand View Research Inc.

 

The global protein stability analysis market size is expected to reach USD 2.0 billion by 2026, expanding at a CAGR of 10.8%, according to a new report by Grand View Research, Inc. Protein stability analysis is an essential step in therapeutics stability studies that enables the assessment of factors causing aggregation and degradation of proteins. This analysis keeps a check on the biologic activity, quality, and product safety of biopharmaceuticals. The recent approvals of recombinant protein therapeutics increase the demand for this analysis during the drug development programs.

Biopharmaceutical innovators are at the forefront of the human response to the coronavirus pandemic. A significant number of major biotech firms are in the midst of a race to investigate the Sars-Cov-2 genome and prepare a viable vaccine for the same. As compared to the speed of response to SARS/MERs etc, the biotech entities are investigating SARs-Cov-2 at an unprecedented rate and a considerable amount of funds are being put into the R&D. With multiple candidates in trial, the public and private sectors are anticipated to work in unison for the foreseeable period, until a vaccine is developed for Covid-19. The report will account for Covid19 as a key market contributor.

Rising R&D in the biopharmaceuticals arena has pronounced the demand for protein stability protocols. The drug manufacturers are adopting the stability-indicating methods for degradation pathway analysis and stress testing for the development of effective and safe therapeutics. Moreover, government agencies are encouraging the drug safety programs by raising funds in the field of proteomics industry, which in turn, surge the adoption of stability analysis.

For instance, in January 2018, funding of USD 18 million from the Genome Canada and Genome BC supported the protein research of the University of Victoria, Canada. Besides, key companies are also entering into collaborations with the venture capitalists for funds to expand their stability analysis portfolio.

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Ionic liquids are extensively applied in biological systems as environmentally friendly solvents. It is crucial to analyze the effect of ionic liquids over protein stability as it is helpful in the analysis of biological reaction processes. A study published in April 2020, evaluated the thermodynamics of protein stability in ionic liquids by the utilization of Fluorine-19 nuclear magnetic resonance spectroscopy. Such studies are expected to increase the adoption of protein stability techniques over the forecast period.

Protein Stability Analysis Market Report Highlights

• Reagents and assay kits accounted for the largest share in 2020 owing to frequent usage of these products and low cost associated with them as compared to other product types
• Broadening application of analytical instruments that are designed to assess several stability-indicating parameters using ultra-low sample volumes at high speed drives the instrument segment with the fastest CAGR
• Differential Scanning Calorimetry (DSC) held the largest revenue share in 2020 due to numerous advantages of DSC over other determination methods
• These benefits include simple sample preparation, easy implementation of DSC in both solid and liquid samples, and determination of thermodynamic parameters
• Differential Scanning Fluorimetry (DSF) technique is expected to register the fastest growth rate due to the rising implementation of nanoDSF technique in analytical studies
• This is attributive to the fact that nanoDSF rapidly and reliably determines the melting point of crude extracts, thus eliminating the requirement for cost and time-intensive protein analysis steps
• Pharmaceutical and biotechnology companies dominated the protein stability analysis market in 2020 due to the presence of well-established drug manufacturers that are capable of performing in-house production of biologics
• Contract Research Organizations (CROs) are anticipated to witness a lucrative growth rate during the forecast period
• CROs provide a range of capabilities in protein engineering with integrated platforms and technologies across various geographical regions to support the development of recombinant protein therapeutics
• A large number of proteomics projects conducted in U.S. and high focus on proteomics research activities by national agencies marks the dominant share of North America
• Asia Pacific is expected to witness the fastest growth rate owing to the rising number of conferences and events conducted to raise awareness about the products available for stability analysis
• Key players such as Enzo Biochem, Thermo Fisher, PerkinElmer, NanoTemper, and GE Healthcare, have adopted several strategic initiatives to reinforce their market presence.

The development of new high-throughput techniques, such as Stable-seq by professionals at The American Society for Biochemistry and Molecular Biology, Inc., which involves genetic selection in combination with high-throughput DNA sequencing is anticipated to induce growth. This approach effectively evaluates the in vivo stability of protein variants, which is important for the identification of components in proteolytic pathways that affect the protein turnover and associated activities.

Outsourcing has been widely employed in the drug development industry as a business strategy to enhance productivity in drug development R&D activities and reduce drug development costs. Several contract research organizations, including 2bind GmbH and LakePharma, Inc., are offering stability analysis solutions with quality, accuracy, and robustness within expected timelines. Moreover, compliance with regulatory expectations supplements the adoption of outsourced services by pharmaceutical companies.

Constant efforts laid down by the research groups to design software tools for analysis of protein stability are expected to drive market growth. CUPSAT, designed by the University of Cologne, is an easily accessible web tool for protein stability analysis based on point mutations. This prediction model serves as a valuable tool for the analysis, with an accuracy greater than 80%.

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The use of thermal proteome profiling (TPP), provides a novel approach for protein stability analysis. TPP is based on the principle that proteins develop a high resistance for heat-induced unfolding by ligand binding. Hence, the improvements in instrumentation and sample preparation for TPP enables the identification of even small stability shifts in proteins.

Key participants operating in the market for protein stability analysis include Thermo Fisher Scientific, Inc; Enzo Biochem, Inc.; PerkinElmer Inc.; NanoTemper; GE Healthcare; HORIBA, Ltd.; Malvern Panalytical Ltd.; Agilent Technologies, Inc.; SETARAM Instrumentation; Unchained Labs; Waters Corporation; and Applied Photophysics Ltd.

Key companies are adopting significant initiatives to reinforce their market presence and maintain a competitive edge in the space. In addition, market participants are involved in product development, collaborative and partnership models, geographic expansion, and agreement strategies in untapped regions.

For instance, in February 2020, NanoTemper Technologies introduced NT. Robotic autosampler, which is designed to automate the researcher’s workflow for screening a wide variety of candidates for protein stability. This new system benefited the company’s protein stability analysis portfolio due to high flexibility and small size, thereby accelerating the company’s sales.

Grand View Research has segmented the global protein stability analysis market based on product, technique, end use:

Protein Stability Analysis Product Outlook (Revenue, USD Million, 2015 - 2026)

·         Reagents and Assay Kits

·         Instruments

·         Consumables and Accessories

·         Software

·         Service

Protein Stability Analysis Technique Outlook (Revenue, USD Million, 2015 - 2026)

·         Chromatography

·         Spectroscopy

·         Differential Scanning Calorimetry (DSC)

·         Differential Scanning Fluorimetry (DSF)

·         Dynamic Light Scattering (DLS)

·         Others

Protein Stability Analysis End-use Outlook (Revenue, USD Million, 2015 - 2026)

·         Pharmaceutical & Biotechnology Companies

·         Contract Research Organizations

·         Academic Research Institutes

About Grand View Research

Grand View Research, Inc. is a U.S. based market research and consulting company, registered in the State of California and headquartered in San Francisco. The company provides syndicated research reports, customized research reports, and consulting services. To help clients make informed business decisions, we offer market intelligence studies ensuring relevant and fact-based research across a range of industries, from technology to chemicals, materials and healthcare.

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